Monash University
L11 Final Revised Submitted Thesis 20190117 pdf_Redacted.pdf (31.69 MB)

Immune biomarkers and infections in kidney transplant recipients

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posted on 2019-03-08, 04:23 authored by CLAIRE DENDLE
The aim of this thesis was to find immune biomarkers that can predict the development of severe infection in kidney transplant recipients. We enrolled 168 clinically stable kidney transplant recipients, undertook baseline immune testing and followed patients prospectively for two years. Thirty-five percent of patients developed an infection. Several biomarkers and a composite score of biomarkers and clinical characteristics could successfully discriminate between patients at very high risk of developing infection and those at a lower risk. These biomarkers can assist clinicians to make decisions about infection prevention and inform future studies aimed at finding safe ways to reduce immunosuppression.


Principal supervisor

Stephen Roger Holdsworth

Year of Award


Department, School or Centre

Clinical Sciences at Monash Health

Additional Institution or Organisation



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences