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Identifying novel targets to treat cognitive impairment in cancer survivors
thesisposted on 16.12.2021, 00:11 by NI-CHUN CHUNG
This thesis investigated the role of cancer and treatments including surgery and chemotherapy on cancer-related cognitive impairment. Using mouse models of breast cancer and behavioural evaluation of memory, this thesis found that cancer-free ‘survivor’ mice show sustained cognitive impairment and neuroinflammation. The findings demonstrate a cumulative and long-lasting impact of multiple cancer-related events on the brain.