Monash University

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Reason: Under embargo until 28 February 2025. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library, or by emailing

Identification of therapeutic vulnerabilities in Atypical Teratoid Rhabdoid Tumour

posted on 2022-02-16, 22:26 authored by HUI SHI
Atypical teratoid rhabdoid tumours (ATRTs) are high-grade malignant paediatric brain tumours with a less than one-year survival rate after diagnosis. Current treatment for ATRT results in long-term side effects on ATRT patients. Here is an urgent need to discover targeted therapies that could be used to treat patients with ATRT. As part of the Hudson Monash Paediatric Precision Medicine Program, this project provides a framework for applying an integrative multi-omics approach in paediatric cancer precision medicine. This thesis demonstrates that ATRT cells preserved clinically relevant genetic architecture, and informed on novel therapeutic strategies for ATRT.


Principal supervisor

Ron Firestein

Year of Award


Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Molecular and Translational Science (Hudson Institute)


Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses