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Identification of therapeutic vulnerabilities in Atypical Teratoid Rhabdoid Tumour
thesisposted on 2022-02-16, 22:26 authored by HUI SHI
Atypical teratoid rhabdoid tumours (ATRTs) are high-grade malignant paediatric brain tumours with a less than one-year survival rate after diagnosis. Current treatment for ATRT results in long-term side effects on ATRT patients. Here is an urgent need to discover targeted therapies that could be used to treat patients with ATRT. As part of the Hudson Monash Paediatric Precision Medicine Program, this project provides a framework for applying an integrative multi-omics approach in paediatric cancer precision medicine. This thesis demonstrates that ATRT cells preserved clinically relevant genetic architecture, and informed on novel therapeutic strategies for ATRT.