Monash University
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Identification of cancer specific endogenous HLA class I peptide repertoire in haematological and paediatric brain malignancy

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posted on 2020-12-18, 01:45 authored by KIRTI PANDEY
Using a combination of high-resolution mass spectrometry (MS) flow cytometry, and other biochemical techniques the study investigates in-depth the immunopeptidome of AML including cell lines and clinical samples. the thesis also thoroughly investigates the immunopeptidome of DIPG, a type of rare and aggressive paediatric glioma. Through our optimised MS workflow, we have identified different peptides which have the potential of being translated at a clinical level for T cell mediated immunotherapy, hence fulfilling the unmet need for DIPG specific treatment.


Principal supervisor

Anthony Purcell

Additional supervisor 1

Nicole Mifsud

Additional supervisor 2

Sri Ramarathinam

Year of Award


Department, School or Centre

Biochemistry and Molecular Biology


Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences