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Identification of cancer specific endogenous HLA class I peptide repertoire in haematological and paediatric brain malignancy

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thesis
posted on 18.12.2020, 01:45 by KIRTI PANDEY
Using a combination of high-resolution mass spectrometry (MS) flow cytometry, and other biochemical techniques the study investigates in-depth the immunopeptidome of AML including cell lines and clinical samples. the thesis also thoroughly investigates the immunopeptidome of DIPG, a type of rare and aggressive paediatric glioma. Through our optimised MS workflow, we have identified different peptides which have the potential of being translated at a clinical level for T cell mediated immunotherapy, hence fulfilling the unmet need for DIPG specific treatment.

History

Principal supervisor

Anthony Purcell

Additional supervisor 1

Nicole Mifsud

Additional supervisor 2

Sri Ramarathinam

Year of Award

2020

Department, School or Centre

Biochemistry and Molecular Biology

Course

Doctor of Philosophy

Degree Type

DOCTORATE

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