Embargoed and Restricted Access
Reason: Under embargo until 30 May 2026. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.
Identification of Targetable Pathway Dependencies in Diffuse Midline Glioma
thesisposted on 2023-05-12, 03:14 authored by SARAH GRACE PARACKAL
Diffuse Midline Glioma (DMG), is a highly aggressive and infiltrative paediatric brain tumour with currently no known cure. Characterisation of DMG has since revealed a diverse molecular landscape with a signature histone H3 mutation (p.K27M). In this study we use a functional genomics approach to identify targetable molecular dependencies to develop into a novel therapeutic and clinically efficacious regimen. The findings of this thesis highlight the importance of using molecularly derived tumour information to develop better treatment outcomes for DMG patients.