Monash University

Embargoed and Restricted Access

Reason: Under embargo until 30 May 2026. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.

Identification of Targetable Pathway Dependencies in Diffuse Midline Glioma

posted on 2023-05-12, 03:14 authored by SARAH GRACE PARACKAL
Diffuse Midline Glioma (DMG), is a highly aggressive and infiltrative paediatric brain tumour with currently no known cure. Characterisation of DMG has since revealed a diverse molecular landscape with a signature histone H3 mutation (p.K27M). In this study we use a functional genomics approach to identify targetable molecular dependencies to develop into a novel therapeutic and clinically efficacious regimen. The findings of this thesis highlight the importance of using molecularly derived tumour information to develop better treatment outcomes for DMG patients.


Principal supervisor

Jason Edward Cain

Additional supervisor 1

Ron Firestein

Year of Award


Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Molecular and Translational Science (Hudson Institute)

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences