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Identification of Targetable Pathway Dependencies in Diffuse Midline Glioma
thesisposted on 2023-05-12, 03:14 authored by SARAH GRACE PARACKAL
Diffuse Midline Glioma (DMG), is a highly aggressive and infiltrative paediatric brain tumour with currently no known cure. Characterisation of DMG has since revealed a diverse molecular landscape with a signature histone H3 mutation (p.K27M). In this study we use a functional genomics approach to identify targetable molecular dependencies to develop into a novel therapeutic and clinically efficacious regimen. The findings of this thesis highlight the importance of using molecularly derived tumour information to develop better treatment outcomes for DMG patients.
Principal supervisorJason Edward Cain
Additional supervisor 1Ron Firestein
Year of Award2023
Department, School or CentreCentral Clinical School
Additional Institution or OrganisationMolecular and Translational Science (Hudson Institute)
CourseDoctor of Philosophy
FacultyFaculty of Medicine, Nursing and Health Sciences