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Identification of Targetable Pathway Dependencies in Diffuse Midline Glioma

thesis
posted on 2023-05-12, 03:14 authored by SARAH GRACE PARACKAL
Diffuse Midline Glioma (DMG), is a highly aggressive and infiltrative paediatric brain tumour with currently no known cure. Characterisation of DMG has since revealed a diverse molecular landscape with a signature histone H3 mutation (p.K27M). In this study we use a functional genomics approach to identify targetable molecular dependencies to develop into a novel therapeutic and clinically efficacious regimen. The findings of this thesis highlight the importance of using molecularly derived tumour information to develop better treatment outcomes for DMG patients.

History

Principal supervisor

Jason Edward Cain

Additional supervisor 1

Ron Firestein

Year of Award

2023

Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Molecular and Translational Science (Hudson Institute)

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences