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Identification and targeting of novel cellular mechanisms to ameliorate cancer associated cachexia

thesis
posted on 02.03.2021, 00:53 by ADAM GEORGE HAGG
Weakness and frailty are serious consequences of muscle wasting that is reported in 80% of cancer patients. Sadly, 1 in 3 cancer sufferers die due to complications of muscle wasting. No therapies exist to address this health issue. This PhD thesis focuses on understanding the biological processes that take place in muscle cells affected by cancer. Findings presented here have significant implications for the management of patients in the clinic and the development of therapies for cancer associated muscle wasting.

History

Principal supervisor

Craig Harrison

Additional supervisor 1

Paul Gregorevic

Year of Award

2021

Department, School or Centre

Physiology

Additional Institution or Organisation

The University of Melbourne, Baker Heart and Diabetes Institute

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE