5746215_OngKuanShionPhDThesis_L317.pdf (10.6 MB)

Identification and Characterization of Pyochelin Produced by a Novel Bacterium Burkholderia paludis

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thesis
posted on 04.01.2018, 04:55 by KUAN SHION ONG
The increase in prevalence of antimicrobial-resistant bacteria in the past decade is a serious global threat, hence there is a need for new antimicrobial compounds to treat bacterial infections. One strategy to look for antimicrobial compounds is by prospecting for novel microorganisms. This thesis characterizes a novel bacterium, Burkholderia paludis along with its antimicrobial compound which is pyochelin. Pyochelin is able to inhibit the growth of antimicrobial-resistant bacteria by enhancing the generation of free radicals. This finding reveals a new function of pyochelin and signifies a promising alternative to treat infections caused by antimicrobial-resistant bacteria.

History

Campus location

Malaysia

Principal supervisor

Sui Mae Lee

Additional supervisor 1

Yuen Lin Cheow

Additional supervisor 2

Learn Han Lee

Year of Award

2018

Department, School or Centre

School of Sciences (Monash University Malaysia)

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Science

Exports

Categories

Exports