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Identification and Characterisation of Novel Therapeutic Targets Associated with Atherosclerotic Plaque Instability

thesis
posted on 29.07.2019, 22:47 by Ya-Lan Ying
Myocardial infarction and stroke are the leading causes of mortality and morbidity worldwide. Rupture of vulnerable plaques and subsequent thrombus formation can ultimately occlude the large blood vessels and be harmful to the patients. The newly described tandem stenosis (TS) mouse model of plaque instability has shed light on our understanding of human plaque destabilisation. The research in this thesis utilised the TS mouse model to investigate the roles of miRNA-142, S100a8/S100a9, Coronin1a in atherosclerosis development and plaque instability, and thus potentially develop effective therapies to prevent atherosclerotic complications in humans.

History

Principal supervisor

Karlheinz

Additional supervisor 1

Peter Meikle

Year of Award

2019

Department, School or Centre

Medicine - Alfred

Additional Institution or Organisation

Baker Heart and Diabetes Institute

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports

Exports