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Identification, Characterization and Function of Olfactory Marker Protein in the Zebrafish Brain

thesis
posted on 12.11.2017, 23:03 by SALMI AB AZIZ
The work presented in this thesis identified a novel isoform of Olfactory marker protein (OMP2) in the brain of zebrafish, which contains 1928 nucleotides. The OMP2 was expressed in neurons in multiple brain regions and was co-localized with gonadotropin-releasing hormone 3 (GnRH3) in the preoptic area (POA). There was a significant decrease in omp2 and gnrh3 mRNA expression levels in the OMP2-knockdown compared to controls. These findings suggest that this new isoform of OMP (OMP2), expressed in neurons, might be involved in reproduction in the zebrafish.

History

Principal supervisor

Ishwar Parhar

Year of Award

2017

Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Additional Institution or Organisation

Brain Research Institute Monash Sunway (BRIMS)

Campus location

Malaysia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences