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Reason: Under embargo until April 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Investigating Inflammatory and Developmental Pathways Underlying Bronchopulmonary Dsyplasia

Version 2 2021-04-01, 04:46
Version 1 2021-04-01, 01:26
thesis
posted on 2021-04-01, 04:46 authored by LAKSHANIE CARMEN WICKRAMASINGHE MUDIYANSELAGE
Bronchopulmonary Dysplasia (BPD) is a debilitating lung disease that affects premature infants. Due to the lack of a cure, novel treatment strategies are urgently required. The primary focus of this PhD thesis was to investigate inflammatory and developmental factors that contribute to the development of BPD. The Immune cell factor, granulocyte colony-stimulating factor was identified as a critical driver of severe lung pathology in BPD, while vascular endothelial growth factor-D, an understudied developmental factor, protected the infant lungs from structural and functional impairment. This research has identified two new disease targets, supporting efforts in therapeutic discovery for BPD treatment.

History

Principal supervisor

Margaret

Additional supervisor 1

Evelyn Tsantikos

Additional supervisor 2

Peter van Wijngaarden

Year of Award

2021

Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Immunology - Alfred

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences