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Revised (Final) Thesis (Alemayehu Jufar).pdf (7.26 MB)

Hypoxia And Inflammation Of The Kidney And Brain During And After Cardiopulmonary Bypass

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thesis
posted on 2023-12-04, 11:52 authored by ALEMAYEHU HAILU JUFAR
This PhD project focuses on the pathophysiology of cardiac surgery-associated acute kidney injury and brain injury and developing methods for detecting sub-clinical kidney injury. We find that renal and cerebral hypoxia and inflammation during cardiopulmonary bypass may play important roles in the pathophysiology of subsequent kidney and brain injury. However, neither hypothermia nor the drug dexmedetomidine prevent the hypoxia and inflammation caused by cardiopulmonary bypass. Renal functional reserve is a potential biomarker for detecting sub-clinical kidney injury. Its recruitment by infusion of amino acids appears to be safe for the kidney, at least in the absence of pre-existing kidney disease.

History

Principal supervisor

Roger George Evans

Additional supervisor 1

Professor Yugeesh Lankadeva

Additional supervisor 2

Professor Clive May

Year of Award

2023

Department, School or Centre

Physiology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences