High strontium-substituted carbonate apatite nanoparticles for delivery of CAMK4-specific siRNA and plasmid-p53 gene in breast cancer cells and tumour mouse model

Breast cancer is the leading cause of cancer death among women worldwide. Nanoparticle-based gene therapy is an emerging field in breast cancer research. High strontium-substituted carbonate apatite (Sr-CA) is a natural salt-based, inorganic nanoparticle that is highly pH-sensitive, physiologically stable, and biologically safe. High Sr-CA nanoparticles depend on calcium-dependent cell signalling pathways and modulate CAMK4 gene expression. Moreover, high Sr-CA nanoparticles have an excellent cargo-carrying capacity and efficiently deliver their loaded cargoes, like genetic materials, in breast cancer cells and tumour mouse model. Therefore, high Sr-CA nanoparticles can be a potential option in the field of nanoparticle-based gene therapy.