Harnessing the regenerative power of the brain using biomaterials for the treatment of Parkinson’s disease

This study addresses the challenges posed by Parkinson's disease (PD), a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. Introducing a novel surgical approach, the study utilizes self-assembling peptide hydrogels to enhance neurogenesis and replace dopamine neurons in the injured adult brain. Investigating the redirection of endogenous neuroblast populations from the subgranular zone to the substantia nigra in rodents, the study explores the feasibility of synthesized peptide hydrogels in facilitating neural stem cell migration. The findings offer potential breakthroughs for treating PD and other brain-related diseases, promising advancements in novel therapeutic interventions.