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Reason: Under embargo until July 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Haploinsufficiency of Murine Nfkb1 Confers a Defective Immune Response and Diverse Late-onset Complications

thesis
posted on 2020-07-07, 07:11 authored by JASPER KEVIN SPENCER CORNISH
Common variable immunodeficiency (CVID) is a disease in which patients show a weak immune response and susceptibility to recurrent infections. With age, CVID patients can develop additional complications, including autoimmune disease and cancer, which can significantly shorten their lives. CVID develops due to mutations in genes that are ordinarily critical for the immune system. The most commonly affected gene in Europeans is NFKB1. However, it was unclear why the NFKB1 gene is required to prevent CVID. This project studied the function of NFκB1 in mice and identified several mechanisms that could give rise to CVID in the relevant human patients.

History

Principal supervisor

Raffi Gugasyan

Additional supervisor 1

George Grigoriadis

Additional supervisor 2

Paul Ramsland

Year of Award

2020

Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Immunology - Alfred

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

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