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HMGB1 as a therapeutic target against epilepsy-related memory impairment in zebrafish

thesis
posted on 24.05.2021, 11:50 by YAM NATH PAUDEL
High mobility group box 1 (HMGB1) protein is a pro-inflammatory like cytokine with plausible role in myriad of neuroinflammation mediated pathologies including epilepsy. Epilepsy is a devastating neurological disorder and cognitive decline is among the prevalent neurobehavioral comorbidities associated with epilepsy. However, the role of HMGB1 on epilepsy induced cognitive impairment is not well reported. This PhD thesis investigates the contribution of HMGB1 protein against epilepsy and related cognitive decline in adult zebrafish and suggest that HMGB1 has a plausible role in developing cognitive impairment post-epilepsy. Hence, therapeutic manipulation of HMGB1 might be beneficial against epilepsy and related cognitive decline.

History

Principal supervisor

Mohmad Farooq Shaikh

Additional supervisor 1

Iekhsan Othman

Year of Award

2021

Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Campus location

Malaysia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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