Monash University

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Reason: Under embargo until May 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

HMGB1 as a therapeutic target against epilepsy-related memory impairment in zebrafish

posted on 2021-05-24, 11:50 authored by YAM NATH PAUDEL
High mobility group box 1 (HMGB1) protein is a pro-inflammatory like cytokine with plausible role in myriad of neuroinflammation mediated pathologies including epilepsy. Epilepsy is a devastating neurological disorder and cognitive decline is among the prevalent neurobehavioral comorbidities associated with epilepsy. However, the role of HMGB1 on epilepsy induced cognitive impairment is not well reported. This PhD thesis investigates the contribution of HMGB1 protein against epilepsy and related cognitive decline in adult zebrafish and suggest that HMGB1 has a plausible role in developing cognitive impairment post-epilepsy. Hence, therapeutic manipulation of HMGB1 might be beneficial against epilepsy and related cognitive decline.


Principal supervisor

Mohmad Farooq Shaikh

Additional supervisor 1

Iekhsan Othman

Year of Award


Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences