Monash University

Embargoed and Restricted Access

Reason: Under embargo until 12 September 2026. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Genetically engineering regulatory T cells to treat systemic lupus erythematosus

posted on 2023-09-12, 08:21 authored by RACHEL MEAU YENN CHEONG
Regulatory T cells (Tregs) play an important role in maintaining immune system homeostasis. In particular, antigen-specific Tregs have been shown to be able to specifically and potently suppress antigen autoreactivity, suggesting there is potential for the development of antigen-specific Tregs to treat autoimmune diseases such as lupus nephritis. This thesis describes a novel method of identifying autoantigen-specific T cell receptors (TCRs) using high throughput single cell sequencing and have shown that our autoantigen-specific Tregs are able to potently suppress and prevent disease progression of lupus nephritis in mouse models of disease.


Principal supervisor

Joshua Daniel King Ooi

Additional supervisor 1

Alberta Hoi

Additional supervisor 2

Eric Morand

Year of Award


Department, School or Centre

Clinical Sciences at Monash Health

Additional Institution or Organisation


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences