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Reason: Under embargo until 12 September 2026. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Genetically engineering regulatory T cells to treat systemic lupus erythematosus
thesisposted on 2023-09-12, 08:21 authored by RACHEL MEAU YENN CHEONG
Regulatory T cells (Tregs) play an important role in maintaining immune system homeostasis. In particular, antigen-specific Tregs have been shown to be able to specifically and potently suppress antigen autoreactivity, suggesting there is potential for the development of antigen-specific Tregs to treat autoimmune diseases such as lupus nephritis. This thesis describes a novel method of identifying autoantigen-specific T cell receptors (TCRs) using high throughput single cell sequencing and have shown that our autoantigen-specific Tregs are able to potently suppress and prevent disease progression of lupus nephritis in mouse models of disease.