Genetic and Proteomic Screening Reveals ß-catenin-dependent Transcriptional Regulation in Colorectal Cancer

Colorectal cancer is one of the most commonly diagnosed and deadly cancers. Aberrant activation of the canonical Wnt pathway is observed in virtually all CRC patients. Despite intense efforts, most of the inhibitors of the pathway have not been translated into the clinic owing mainly to the observations of toxicity and nontumor-specific normal inhibition in preclinical models. To overcome this challenge, our lab performed genetic and proteomic screening of dysregulated Wnt signalling, and identified several regulators exclusively contributing to Wnt-responsive oncogene expression. This opens a novel window to block Wnt-induced colon tumorigenesis with the lower rate of off-target influences on homeostatic maintenance.