Monash University
Final Thesis (Michael Pellegrini).pdf (89.32 MB)

Genetic Polymorphisms and Response Variability to Transcranial Direct Current Stimulation of the Primary Motor Cortex

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posted on 2020-11-09, 00:55 authored by MICHAEL JAMES PELLEGRINI
This thesis investigates mechanisms of neuroplasticity that underpin changes in brain activity following non-invasive brain stimulation techniques. It investigates previous observations that not all individuals respond to non-invasive brain stimulation in the same manner. It explores whether differences in expression of particular genes involved in neuroplasticity may explain this variability in response. This thesis reported that the expression of two specific genes were associated with how individuals respond to non-invasive brain stimulation. These findings offer novel insights into the future use of genetic biomarkers as a potential screening tool for suitability of non-invasive brain stimulation techniques in the clinical setting.


Principal supervisor

Shapour Jaberzadeh

Additional supervisor 1

Maryam Zoghi

Year of Award


Department, School or Centre

Primary and Allied Health Care

Additional Institution or Organisation


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences