GENETIC AND EPIGENETIC FACTORS THAT DETERMINE RESPONSE TO THERAPY IN CANCER

Advances in cancer treatments over the last few years have resulted in improved outcomes for patients. However, to further improve survival, it is vital that cancer treatments are selected on the likelihood of response in each individual patient; decisions should no longer be based on a one-size-fits-all approach. This thesis examines the practical aspects of detecting the genetic make-up of patients and their tumours, and explores ways in which this pharmacogenomic information can inform and individualise cancer treatment with the aim of improving outcomes for cancer patients.