Monash University
Ekram_Pre-frailty_Frailty_Thesis_Modified.pdf (7.93 MB)

Frailty and pre-frailty in community-dwelling older adults

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posted on 2024-03-25, 17:19 authored by A R M SAIFUDDIN EKRAM
Frailty, a condition indicating vulnerability to health decline, was studied in 19,114 healthy older adults in Australia and the US. Among them, 2%-11% were frail depending on the assessment tool, and about 40% were pre-frail at the study’s beginning. It examined impact of frailty on heart disease, dementia, physical disability, and mortality over a five-year period. Depression and polypharmacy (taking five or more medications) emerged as potentially modifiable factors, with polypharmacy being associated with more pre-frailty/frailty. Being pre-frail/frail was associated with higher risks of death, heart disease, dementia, and independence-limiting physical disability. Early identification of pre-frail/frail individuals could inform new strategies for healthy aging.


Principal supervisor


Additional supervisor 1

Joanne Ryan

Additional supervisor 2

Sara E Espinoza

Additional supervisor 3

Michael E Ernst

Year of Award


Department, School or Centre

Epidemiology and Preventive Medicine

Additional Institution or Organisation

Monash University

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences