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Formulation of Casein Nanomicelles as a Novel Anticancer Drug Delivery System

thesis
posted on 07.02.2021, 16:21 authored by Farah Rehan
In the present research, we fabricated and characterized the self-assembled sodium caseinate nanomicelles (NaCNs) successfully followed by loading of Paclitaxel (PTX) and Doxorubicin (DOX) into the casein micelle for higher cellular uptake and cytoxicity and further explored antitumour efficacy and biodistribution studies of NaCNs and drug-loaded NaCNs against a murine breast cancer model, where both PTX- and DOX-loaded NaCNs showed enhanced in vivo antitumour efficacy through inhibition of tumour growth. Thus NaCNs can be suggested as safe and non-toxic delivery system with excellent anti-tumour efficacy and can be a potential option for oral chemotherapy.

History

Campus location

Malaysia

Principal supervisor

Gan Siew Hua

Additional supervisor 1

Md. Ezharul Hoque

Additional supervisor 2

Nafees Ahemad

Additional supervisor 3

Manish Gupta

Additional supervisor 4

Varghese Swamy, Farooq Shaikh

Year of Award

2021

Department, School or Centre

School of Pharmacy (Malaysia)

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences