Follistatin and the breast implant capsule

This thesis examines the effect of follistatin treatment on inflammation and fibrosis around silicone implants in mice as well as different methods of follistatin delivery. It establishes that a single injection of follistatin directly around the implant at the time of silicone implant insertion and a single injection of follistatin-impregnated hydrogel at the time of silicone implant insertion into the mice both result in a significant reduction in peri-capsular inflammation and capsular fibrosis.