Monash University
6297602_VREES_25850083_THESIS_FINAL.pdf (5.35 MB)

Fighting resistant bacterial 'superbugs' by novel antibiotic combination dosing strategies

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posted on 2018-05-22, 03:35 authored by VANESSA EMILY REES
Antibiotic resistance in bacterial ‘superbugs’ poses one of the greatest threats to human health worldwide, with fears of a return to the pre-antibiotic era. This is especially problematic for patients with cystic fibrosis who are prone to bacterial respiratory infections. Antibiotic therapies against bacterial pathogens such as Pseudomonas aeruginosa are often ineffective at preventing the emergence of resistance. This thesis identified clinically relevant, synergistic antibiotic combinations to combat P. aeruginosa ‘superbugs’. Ultimately, this thesis contributes to the optimisation of rational antibiotic combination dosage regimens for cystic fibrosis patients infected with P. aeruginosa.


Campus location


Principal supervisor

Cornelia Barbara Landersdorfer

Additional supervisor 1

Jürgen B. Bulitta

Additional supervisor 2

Roger L. Nation

Year of Award


Department, School or Centre

Centre for Medicine Use and Safety (CMUS)


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences