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Fetal growth restriction and brain connectivity: Can lactoferrin restore the deficits?

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posted on 2023-07-05, 05:32 authored by INGRID IRENE MARGREET DUDINK
Ingrid published a new technical optical imaging and analysis protocol for the quantification of neuronal morphology. This has already been used by investigators globally, and here, it was used to characterise brain microstructure during the last third of gestation. This provided a platform to measure the deficits in brain connectivity, in pregnancies complicated by a common, but serious, condition termed fetal growth restriction. Unprecedented data has been shown whereby, there is an altered growth trajectory of neurons. This provided the framework to test a new and exciting novel neuroprotective therapy, called lactoferrin, which has shown promising translational evidence to protect the developing fetal brain.

History

Principal supervisor

Suzanne Lee Miller

Additional supervisor 1

Beth Allison

Additional supervisor 2

Amy Sutherland

Year of Award

2023

Department, School or Centre

Clinical Sciences at Monash Health

Additional Institution or Organisation

Obstetrics and Gynaecology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

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