Feasibility of computerised cognitive training in improving cognitive, psychosocial, and neural outcomes in Huntington's disease

Huntington’s disease (HD) is a genetically inherited neurodegenerative disease that causes cognitive decline. Currently, there are no treatments for cognitive symptoms in HD. This thesis aimed to investigate the feasibility of a large-scale trial of computerised cognitive training (brain training) in HD, and potential effects on cognition, psychosocial wellbeing, brain structure, and brain networks, through a pilot trial. Findings showed potential feasibility of a larger-scale trial. There was evidence of benefits to cognition and brain structure. However, there were no benefits to psychosocial wellbeing or brain networks. This thesis supports the ongoing development of cognitive interventions in HD.