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Reason: Under embargo until March 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Failure to progress in labour: influence of BMI and maternal age

posted on 11.03.2021, 08:18 authored by E Arachchige Ranga Iroshanie Edirisinghe Siriwardhana
Would you believe that, in the face of all medical advances, we have only one drug to help women with poor labour contractions? Currently the only available option to overcome failed labour is caesarean delivery which can put the health of mothers and their offspring at risk of complications. The challenges in developing mother- and child-safe drugs have held scientists back for decades. It is high time for new approaches. Here we have taken the first steps to address this by identifying potential targets for developing drugs to produce strong contractions in the uterus that will promote successful vaginal delivery.


Principal supervisor

Helena Parkington

Additional supervisor 1

Harold Coleman

Additional supervisor 2

Shaun Brennecke

Additional supervisor 3

Penny Sheehan

Year of Award


Department, School or Centre


Additional Institution or Organisation

Maternal Fetal Medicine Pregnancy Research centre, Royal Women's Hospital, Melbourne, Victoria, Australia

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences