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Reason: Under embargo until 27 February 2024. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.
Fabrication, Characterization and Evaluation of Hybrid Organic-Inorganic Nano-Carriers for Delivery of Doxorubicin in Breast Cancer Cells
thesis
posted on 2023-02-18, 00:37 authored by SHEIKH TANZINA HAQUECarbonate apatite (CA) nanoparticles (NPs) basically composed of Ca2+, PO43- and CO32-, tend to self-aggregate, resulting in insufficient drug binding efficiency and off-target distribution to healthy tissues. To overcome the limitation, CA NPs were modified with Fe3+ and Mg2+ and subsequently, with anionic Krebs’ cycle intermediates and lactate to modulate the particles size, surface charge, and morphology. The resultant small size, monodisperse pH-sensitive NPs of Fe/Mg-CA demonstrated increased binding affinity for Doxorubicin (anti-cancer drug) and thereby led to enhanced antiproliferative effect, cellular uptake, tumor-targeted drug delivery, and reduced systemic toxicity and tumor growth in a breast cancer syngeneic mouse model.
