Monash University
Browse

Exploring the Structure and Dynamics of Amylin Receptors

thesis
posted on 2025-04-29, 23:38 authored by Cameron James Fairweather
Membrane receptors are proteins located on the surface of cells that are involved in almost all physiological functions, transmitting signals from outside of the cell into responses inside the cell. In this thesis, we used high-resolution microscopy and biophysical techniques to show that the three receptors for the hormone amylin display different structural dynamics, contributing to their unique characteristics. Additionally, we found that different hormones modulate the dynamics of the amylin receptors in unique ways. These findings improve our understanding of how these receptors function and will benefit future drug development.

History

Campus location

Australia

Principal supervisor

Tracy Josephs

Additional supervisor 1

Patrick Sexton

Additional supervisor 2

Xin Zhang

Year of Award

2025

Department, School or Centre

Drug Discovery Biology

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

Usage metrics

    Faculty of Pharmacy and Pharmaceutical Sciences Theses

    Keywords

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC