Monash University

Embargoed and Restricted Access

Reason: Under embargo until 30 January 2024. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library,

Exploring the Interplay Between a High Salt Diet, Intestinal Health, and Atherosclerosis

posted on 2023-01-30, 22:20 authored by OLIVIA DAWN COONEY
A western diet contains high amounts of salt, which is a known risk factor for heart disease. Previously, salt has been associated with heart disease through an increase in blood pressure. However, a high salt diet can also directly increase inflammatory white blood cells. In my PhD, I discovered that a high salt intake can increase inflammatory white blood cells triggered by the gut which enters the heart and increases heart disease risk. Interestingly, restoring gut health using prebiotics, significantly reduces inflammatory white blood cells and heart disease risk, highlighting an important role the gut plays in salt-related heart disease.


Principal supervisor

Andrew Murphy

Additional supervisor 1

Man Kit Sam Lee

Year of Award


Department, School or Centre

Immunology - Alfred

Additional Institution or Organisation

Baker Heart and Diabetes Institute

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences