Exploring the Impact of Radiotherapy Modality and Dose Escalation for High-Risk Prostate Cancer Patients: Applications of Accumulated Dose in Toxicity Predictions

This thesis explored the impact of radiotherapy modality and dose escalation for high-risk prostate cancer patient treatments. This research highlights the potential of combining cutting-edge imaging, photon and proton therapy to improve therapeutic outcomes. The daily delivered radiation dose that accounts for organ motion was utilised to develop predictive models, which were used to estimate the likelihood of occurrence of gastrointestinal and genitourinary toxicities. Integrating parameters derived from biological models further enhanced the toxicity predictions. This study offers a significant contribution towards personalised, precision radiotherapy with improved patient quality of life and treatment efficacy.