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Rupasinghe_Samoda_PhD_Thesis_FINAL.pdf (20.64 MB)

Exploring and Targeting Immune Mechanisms in Ischaemic Stroke

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thesis
posted on 2023-07-27, 22:18 authored by R A SAMODA AYESHANI RUPASINGHE
Ischaemic stroke is a debilitating disease that elicits a significant inflammatory response within the brain and has few treatment options. Micro products released by stem cells, known as exosomes, have fewer limitations yet possess the same beneficial properties as their parent stem cells. This project investigated novel inflammatory mechanisms within the brain following ischaemic stroke. Furthermore, it examined the ability of exosomes from placental stem cells to improve functional and histological outcomes when given after stroke in mice with or without high blood pressure.

History

Principal supervisor

Bradley Randal Scott Broughton

Year of Award

2023

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Pharmacology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences