posted on 2019-09-17, 03:17authored byJAMES DUC HUNG ONG
This thesis explores the expression and activation of the NLRP3 inflammasome, a protein complex in the immune system, in cells and mice under healthy and disease models. The studies have been conducted using novel reporter mice, where fluorescent proteins are attached to components of the inflammasome that are produced at similar levels to those of a normal laboratory mouse. Findings from these studies have established a new paradigm of how the inflammasome works under biological conditions and validate the use of novel reporter mice to investigate the role of the NLRP3 inflammasome in different diseases.
History
Principal supervisor
Ashley Mansell
Additional supervisor 1
Michelle Tate
Year of Award
2019
Department, School or Centre
Central Clinical School
Additional Institution or Organisation
Molecular and Translational Science (Hudson Institute)