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Evaluation of zinc oxide nanoparticles as a neuroprotective agent on paraquat-induced oxidative stress neuronal model for Parkinson’s disease

thesis
posted on 2024-05-17, 01:14 authored by WESLEY ZHI CHUNG SEE
Parkinson’s disease (PD) is a neurodegenerative condition impacting motor function. The herbicide paraquat has been linked to PD development, with oxidative stress being a key contributor to PD pathogenesis. Conversely, zinc oxide nanoparticles (ZnO-NPs) exhibit neuroprotective potential through its anti-oxidant and anti-apoptotic activities. This study explore ZnO-NPs potential against paraquat-challenged human SH-SY5Y cells. Paraquat alone induced oxidative stress, mitochondrial dysfunction, and apoptosis. Contrastingly, ZnO-NPs pre-treatment demonstrates anti-apoptotic effects by reducing caspase-3/7 activity. The proteomics analysis also suggest ZnO-NPs actively contribute to maintaining proteostasis and enhancing mitochondrial function, offering insights into their potential neuroprotective role in this in vitro PD model.

History

Principal supervisor

Rakesh Naidu

Additional supervisor 1

Tang Kim San

Year of Award

2024

Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Additional Institution or Organisation

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Campus location

Malaysia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

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