Monash University

Embargoed and Restricted Access

Reason: Under embargo until May 2021. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Evaluation of inorganic nano-crystals as potential tools for delivery of siRNA targeting ion channels and transporters in breast cancer cells

posted on 2020-05-31, 13:10 authored by MOHAMMAD BORHAN UDDIN
Carbonate apatite nanoparticles have been explored to deliver siRNA with a goal to inhibit the expression of certain endogenous genes that stimulate the tumour cell growth, to prevent the multiple drug resistance (MDR) problem encountered in cancer therapy. In this research study, the roles of ion channels and transporters in breast cancer survival and proliferation were investigated with standard and modified CA nanoparticles. Hybrid CA was synthesized with different organic polymeric materials and these particles demonstrated significant reduction in viability of breast cancer cells, indicating that ion channels are potential therapeutic targets that could be subjected to siRNA-mediated silencing to treat cancer.


Principal supervisor

Ezharul Hoque Chowdhury

Additional supervisor 1

Prof Mark M. Banaszak Holl

Additional supervisor 2

Dr. Mohd Farooq Shaikh

Year of Award


Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences