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Reason: Under embargo until 10 June 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Evaluation of Novel Cell Repair Compounds as Potential Treatments for Chronic Obstructive Pulmonary Disease (COPD)

posted on 2023-03-17, 00:32 authored by WEIYI MAO

This thesis evaluated the therapeutic effects of various AusBio Ltd-developed novel cell repair (MD990) compounds, as potential treatments for chronic obstructive pulmonary disease (COPD), in a cigarette smoke-induced murine model of COPD. The completed studies provide for the first time, a demonstrated link between the restoration of sialic acid expression levels within the airway epithelium (by these compounds) to the reduction or attenuation of various COPD-related pathologies and dysfunction that results from prolonged cigarette smoke exposure. Hence, this thesis has identified that sialic acid restoration may be a novel therapeutic strategy for treating COPD.


Principal supervisor

Chrishan Samuel

Additional supervisor 1

Simon Royce

Year of Award


Department, School or Centre


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences