Embargoed and Restricted Access
Reason: Under embargo until 10 June 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Evaluation of Novel Cell Repair Compounds as Potential Treatments for Chronic Obstructive Pulmonary Disease (COPD)
This thesis evaluated the therapeutic effects of various AusBio Ltd-developed novel cell repair (MD990) compounds, as potential treatments for chronic obstructive pulmonary disease (COPD), in a cigarette smoke-induced murine model of COPD. The completed studies provide for the first time, a demonstrated link between the restoration of sialic acid expression levels within the airway epithelium (by these compounds) to the reduction or attenuation of various COPD-related pathologies and dysfunction that results from prolonged cigarette smoke exposure. Hence, this thesis has identified that sialic acid restoration may be a novel therapeutic strategy for treating COPD.