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Evaluating the therapeutic effects of bone marrow-derived mesenchymal stem cell-based therapies in combination with an anti-fibrotic agent in experimental models of hypertension

thesis
posted on 2023-08-04, 08:15 authored by YIFANG LI
Chronic kidney disease (CKD) affects 11% Australian population, representing an inexorably growing burden to the Australian healthcare system with no effective cure. Recently, researchers have reported human bone marrow-derived mesenchymal stromal cells (BM-MSCs) as a novel treatment candidate due to their well-established capacity in kidney repairing, this ability, however, can be irreversibly compromised in severe CKD settings due to the build-up of renal fibrosis (scarring). To translate BM-MSC therapy into a definitive cure for two million Australians with CKDs, in this thesis, I evaluated the effectiveness of BM-MSCs combined with a hormone that reduces tissue scarring, relaxin, in managing CKD.

History

Principal supervisor

Chrishan Samuel

Additional supervisor 1

Sharon Ricardo

Year of Award

2023

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Pharmacology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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