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Epigenetic Biomarkers in Pre-symptomatic and Diagnosed Dementia

thesis
posted on 24.11.2020, 02:32 authored by PETER DANIEL FRANSQUET
Diagnosing dementia is a very long and complex process, and there is no way to accurately determine who will get dementia. This thesis aimed to determine whether a blood test could be used to diagnose dementia and predict future risk. It was found that people with dementia have different small molecules attached to their DNA (‘DNA methylation’) in their blood, not only at the time of diagnosis, but also many years before they had dementia symptoms. These findings provide some of the first evidence that a simple blood test may help in diagnosing dementia, even before symptoms occur.

History

Principal supervisor

Joanne

Additional supervisor 1

Paul Lacaze

Additional supervisor 2

Richard Saffery

Additional supervisor 3

Robyn Woods

Year of Award

2020

Department, School or Centre

Epidemiology and Preventive Medicine

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences