Monash University

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Reason: Under embargo until November 2021. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Epigenetic Biomarkers in Pre-symptomatic and Diagnosed Dementia

posted on 2020-11-24, 02:32 authored by PETER DANIEL FRANSQUET
Diagnosing dementia is a very long and complex process, and there is no way to accurately determine who will get dementia. This thesis aimed to determine whether a blood test could be used to diagnose dementia and predict future risk. It was found that people with dementia have different small molecules attached to their DNA (‘DNA methylation’) in their blood, not only at the time of diagnosis, but also many years before they had dementia symptoms. These findings provide some of the first evidence that a simple blood test may help in diagnosing dementia, even before symptoms occur.


Principal supervisor


Additional supervisor 1

Paul Lacaze

Additional supervisor 2

Richard Saffery

Additional supervisor 3

Robyn Woods

Year of Award


Department, School or Centre

Public Health and Preventive Medicine

Additional Institution or Organisation

Department of Epidemiology and Preventive Medicine

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences