Entry of paracetamol and olanzapine into developing rat and Monodelphis brains and correlation with their transcriptomes: the importance of placental protection

Currently, many pregnant and breastfeeding women regularly take medications, however information on the entry and effects of these drugs on the developing child is limited. This Thesis aimed to identify and test the functionality of drug entry mechanisms present at the brain and placental barriers at different stages of development using paracetamol and olanzapine as test drugs. Overall, the present results suggest that drug entry is determined by a multitude of factors while also invoking several off-target gene changes which should be taken into account for designing safe and effective drug treatment that may need modification depending on developmental age.