Enhancing the Efficacy of the Malaria Vaccine Candidate MSP2 through Lipid Interactions

The work in this thesis describes the efforts to enhance the efficacy of malaria vaccine candidates based on merozoite surface protein 2 (MSP2). The suitability of liposomal formulation as an adjuvant was assessed by studying the immune response to MSP2 in mice. Identifying the functional epitopes was also a focus of my work which will facilitate the development of an effective MSP2-based vaccine candidate. The results of this work provide a valuable platform for the future development of vaccines targeting surface antigens formulated with liposomes without the requirement of additional adjuvants.