Monash University

Embargoed and Restricted Access

Reason: Under embargo until June 2018. After this date a copy can be supplied under Section 51 (2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Engineering adhesive proteins enhanced by self-assembling peptide and enzyme cross-linking

posted on 2017-06-19, 23:27 authored by JAMIE JOSEPH CASTILLO
Conventional adhesives efficiently work on dry surfaces but fail in the presence of water. Currently, there is a great need for adhesives in surgical procedures and underwater construction. Nature gives a hint on how to develop wet adhesives. Mussels survive harsh underwater conditions by secreting an adhesive which attaches to different surfaces. However, natural extraction was found uneconomical. Recombinant engineering approach is a promising alternative method for large-scale adhesive production. Unfortunately, recombinant adhesives face drawbacks such as low performance. This thesis aims to address these drawbacks by designing and synthesising recombinant adhesives, developing a bioproduction, and evaluating their performance.


Campus location


Principal supervisor

Lizhong He

Additional supervisor 1

Victoria Haritos

Year of Award


Department, School or Centre

Chemical & Biological Engineering

Additional Institution or Organisation

Chemical Engineering


Master of Engineering Science (Research)

Degree Type



Faculty of Engineering