Final thesis with Amendments.pdf (43.39 MB)
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Engineering Sensors to Investigate the Intracellular Trafficking of Nanomaterials

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posted on 10.05.2018, 04:49 by LAURA INA SELBY
Nanomaterials are a promising avenue to address issues associated with traditional drug delivery. Drug encapsulation and targeting has the potential to direct cargo to specific cell types, avoiding off-target effects while offering protection to delicate therapeutics. However, our understanding of how cells interact with nanomaterials is lacking. This thesis details the design and synthesis of fluorescent sensors to study the uptake and trafficking of nanomaterials within cells. In addition, a mathematical process is detailed for improving flow cytometry data analysis. Together, this set of tools can be used to improve the understanding of how nanomaterials interact with cells.


Campus location


Principal supervisor

Angus Johnston

Additional supervisor 1

Christopher Porter

Year of Award


Department, School or Centre

Drug Delivery, Disposition and Dynamics


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences