Monash University
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Engineered vertically-aligned polymeric nanostructures for intracellular delivery to mammalian cells

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thesis
posted on 2023-08-17, 23:33 authored by HAO ZHE YOH
Silicon nanoneedles emerged as powerful therapeutic tools to deliver wide range of biocargoes into cells. But their fabrication process is usually complex and costly. The thesis features a new class of engineered nanoneedles that is made of flexible polymeric materials. The nanoneedles can be integrated into cell culture polystyrene with a relatively simple and cost-effective fabrication pathway. This new platform can effectively deliver mRNA into different cell types, and help to reveal the nanoneedle-mediated delivery mechanism at the cellular level.

History

Campus location

Australia

Principal supervisor

Roey Elnathan

Additional supervisor 1

Yaping Chen

Additional supervisor 2

Maria Alba

Additional supervisor 3

Helmut Thissen

Year of Award

2023

Department, School or Centre

Drug Delivery, Disposition and Dynamics

Additional Institution or Organisation

Commonwealth Scientific and Industrial Research Organization (CSIRO)

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences