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Endosome NOX2 oxidase promotes viral pathogenicity and provides a potential target for novel antiviral therapies

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thesis
posted on 08.05.2017, 02:52 by EUNICE ELIZABETH TO
Viral infections pose an imminent global health threat, and with emerging anti-viral resistance and delays in vaccine development, there is an urgent need for novel therapeutic approaches to target host-cell interactions, irrespective of the infecting strain. This thesis has advanced our understanding of endosome biology and cell signalling of viruses, by identifying a fundamental mechanism of virus pathogenicity involving NOX2 and TLR7. We have identified a novel drug that inhibits endosomal ROS generation to alleviate influenza A virus pathology and potentially other globally devastating viruses.

History

Principal supervisor

Stavros Selemidis

Year of Award

2017

Department, School or Centre

Pharmacology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

Doctorate

Faculty

Faculty of Medicine Nursing and Health Sciences

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