Endosome NOX2 oxidase promotes viral pathogenicity and provides a potential target for novel antiviral therapies

Viral infections pose an imminent global health threat, and with emerging anti-viral resistance and delays in vaccine development, there is an urgent need for novel therapeutic approaches to target host-cell interactions, irrespective of the infecting strain. This thesis has advanced our understanding of endosome biology and cell signalling of viruses, by identifying a fundamental mechanism of virus pathogenicity involving NOX2 and TLR7. We have identified a novel drug that inhibits endosomal ROS generation to alleviate influenza A virus pathology and potentially other globally devastating viruses.