Monash University
L93 20181117 PhD Final signed Amended_Redacted.pdf (48.59 MB)

Emergence and Margins in Head and Neck Cancer: A new understanding

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posted on 2019-03-13, 22:18 authored by ELIZABETH ANNE SIGSTON
Cancer has been widely accepted as a genetic disease. This thesis challenges this assumption and proposes that cancer be considered as an emergent complex system. A new framework for carcinogenesis and cancer progression is presented. This framework is applied to identify biological markers with the potential to predict recurrence in oral cancer. A simple dual staining technique is developed to test the identified biomarkers. The results support the use of these biomarkers as a predictor of recurrence over and above traditionally measured cancer clearance.


Principal supervisor

Bryan Williams

Additional supervisor 1

Julian Smith

Year of Award


Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Molecular and Translational Science (Hudson Institute)

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences