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Elucidating the molecular regulation of the dendritic cell receptor, Clec9A

thesis
posted on 11.05.2022, 04:25 by NICOLE MICHAEL
Dendritic cells are the immune cells critical in vaccination as they sense danger and initiate immunity. Clec9A is a Dendritic cell receptor that is the target for novel vaccine technologies that enhance immunity to cancers and viruses. Our research identified a novel regulatory pathway for Clec9A. Clec9A interacts with other proteins, namely RNF41, ERLIN1/2 and TMEM59. ERLIN/2 and RNF41 promote the degradation of Clec9A, while TMEM59 enhances the display of Clec9A at the dendritic cell surface potentially to enhance Clec9A-mediated immune responses. These novel pathways may ultimately be exploited to enhance Clec9A-based vaccines and promote immunity to cancer.

History

Principal supervisor

Mireille Hanna Lahoud

Additional supervisor 1

Mark Wright

Year of Award

2022

Department, School or Centre

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences