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Elucidating the diverse molecular roles of Z-disk proteins in muscle

thesis
posted on 2023-06-22, 10:48 authored by EMILY ANNE MCKAIGE
Inherited skeletal myopathies are muscle diseases characterised by muscle wasting and movement difficulties. Currently, many myopathy patients do not have a genetic diagnosis and for those that do have a diagnosis, we do not understand why these genes are important for muscle function. In this thesis, I analyse one candidate myopathy gene and two known myopathy genes using zebrafish as a model system. Evaluation of these zebrafish models provides insight into the role of these genes in the muscle and identifies potential therapeutic targets for skeletal myopathy.

History

Campus location

Australia

Principal supervisor

Robert Bryson-richardson

Additional supervisor 1

Travis Johnson

Year of Award

2023

Department, School or Centre

Biological Sciences

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Science

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